Ownership Submission

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:

3235-0104

Estimated average burden hours per response...

0.5

(Print or Type Responses)

1. Name and Address of Reporting Person ^*

Smith Stan

2. Date of Event Requiring Statement (Month/Day/Year)
07/27/2022

3. Issuer Name and Ticker or Trading Symbol
MAIA Biotechnology, Inc. [MAIA]

(Last)

(First)

(Middle)

444 WEST LAKE STREET, SUITE 1700

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

__X__ Director	_____ 10% Owner
_____ Officer (give title below)	_____ Other (specify below)

5. If Amendment, Date Original Filed(Month/Day/Year)

(Street)

CHICAGO, IL 60606

6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	296,128	I	See Footnote ⁽¹⁾

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Stock Options	⁽²⁾	05/20/2030	Common Stock	25,000	$ 1.8	I	See Footnote ⁽¹⁾
Stock Options	⁽²⁾	11/02/2030	Common Stock	27,138	$ 1.8	I	See Footnote ⁽¹⁾
Stock Options	⁽³⁾	11/14/2030	Common Stock	18,000	$ 1.8	I	See Footnote ⁽¹⁾
Stock Options	⁽⁴⁾	01/28/2031	Common Stock	4,584	$ 1.8	I	See Footnote ⁽¹⁾
Stock Options	⁽⁵⁾	11/14/2031	Common Stock	18,000	$ 10	I	See Footnote ⁽¹⁾
Stock Options	⁽⁵⁾	11/14/2031	Common Stock	5,000	$ 10	I	See Footnote ⁽¹⁾
Warrants	⁽⁶⁾	⁽⁶⁾	Common Stock	4,517	$ 6	I	See Footnote ⁽¹⁾
Warrants	⁽⁷⁾	⁽⁷⁾	Common Stock	862	$ 6	I	See Footnote ⁽¹⁾
Warrants	⁽⁸⁾	⁽⁸⁾	Common Stock	1,288	$ 6	I	See Footnote ⁽¹⁾
Warrants	⁽⁹⁾	⁽⁹⁾	Common Stock	23,580	$ 6	I	See Footnote ⁽¹⁾
Warrants	⁽¹⁰⁾	⁽¹⁰⁾	Common Stock	2,138	$ 6	I	See Footnote ⁽¹⁾
Warrants	⁽¹¹⁾	⁽¹¹⁾	Common Stock	8,499	$ 6	I	See Footnote ⁽¹⁾
Warrants	⁽¹²⁾	⁽¹²⁾	Common Stock	2,120	$ 6	I	See Footnote ⁽¹⁾
Warrants	⁽¹³⁾	⁽¹³⁾	Common Stock	2,121	$ 6	I	See Footnote ⁽¹⁾
Warrants	⁽¹⁴⁾	⁽¹⁴⁾	Common Stock	2,119	$ 6	I	See Footnote ⁽¹⁾

Reporting Owners

Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Smith Stan 444 WEST LAKE STREET, SUITE 1700 CHICAGO, IL 60606	X

Signatures

/s/ Stan V. Smith		07/27/2022
^**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	These securities are beneficially owned by Mr. Smith through The Stan V. Smith Trust Dated 1993.
(2)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options fully vested on May 20, 2021.
(3)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options vested in 12 equal monthly installments beginning on December 15, 2020.
(4)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options vested in 12 equal monthly installments beginning on January 29,2021.
(5)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options vest in 12 equal monthly installments beginning on November 15, 2021.
(6)	Each Warrant became exercisable on the date of issuance of May 06, 2020, and expires on the earliest to occur of: (a) May, 31, 2027 or (b) immediately prior to the closing of any change of control of the issuer.
(7)	Each Warrant became exercisable on the date of issuance of March 08, 2021, and expires on the earliest to occur of: (a) March, 7, 2028 or (b) immediately prior to the closing of any change of control of the issuer.
(8)	Each Warrant became exercisable on the date of issuance of March 29, 2021, and expires on the earliest to occur of: (a) March 28, 2028 or (b) immediately prior to the closing of any change of control of the issuer.
(9)	Each Warrant became exercisable on the date of issuance of April 07, 2021, and expires on the earliest to occur of: (a) April 6, 2028 or (b) immediately prior to the closing of any change of control of the issuer.
(10)	Each Warrant became exercisable on the date of issuance of April 23, 2021, and expires on the earliest to occur of: (a) April 22, 2028 or (b) immediately prior to the closing of any change of control of the issuer.
(11)	Each Warrant became exercisable on the date of issuance of June 1, 2021, and expires on the earliest to occur of: (a) May 31, 2028 or (b) immediately prior to the closing of any change of control of the issuer.
(12)	Each Warrant became exercisable on the date of issuance of June 11, 2021, and expires on the earliest to occur of: (a) June10, 2028 or (b) immediately prior to the closing of any change of control of the issuer.
(13)	Each Warrant became exercisable on the date of issuance of June 15, 2021, and expires on the earliest to occur of: (a) June 14, 2028 or (b) immediately prior to the closing of any change of control of the issuer.
(14)	Each Warrant became exercisable on the date of issuance of June 18, 2021, and expires on the earliest to occur of: (a) June 17, 2028 or (b) immediately prior to the closing of any change of control of the issuer.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.