Ownership Submission

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:

3235-0104

Estimated average burden hours per response...

0.5

(Print or Type Responses)

1. Name and Address of Reporting Person ^*

Gryaznov Sergei

2. Date of Event Requiring Statement (Month/Day/Year)
07/27/2022

3. Issuer Name and Ticker or Trading Symbol
MAIA Biotechnology, Inc. [MAIA]

(Last)

(First)

(Middle)

444 WEST LAKE STREET, SUITE 1700

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

_____ Director	_____ 10% Owner
__X__ Officer (give title below)	_____ Other (specify below)
Chief Scientific Officer

5. If Amendment, Date Original Filed(Month/Day/Year)

(Street)

CHICAGO, IL 60606

6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	21,511 ⁽¹⁾	D

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Stock Options	⁽²⁾	11/30/2029	Common Stock	200,000	$ 1.8	D
Stock Options	⁽³⁾	11/30/2029	Common Stock	58,000	$ 1.8	D
Stock Options	⁽⁴⁾	04/01/2030	Common Stock	54,000	$ 1.8	D
Stock Options	⁽⁵⁾	11/02/2030	Common Stock	236,493	$ 1.8	D
Stock Options	⁽⁶⁾	12/31/2030	Common Stock	23,695	$ 1.8	D
Stock Options	⁽⁷⁾	04/15/2031	Common Stock	164,662	$ 1.83	D
Stock Options	⁽⁸⁾	04/15/2031	Common Stock	78,413	$ 1.83	D
Stock Options	⁽⁹⁾	03/31/2031	Common Stock	23,078	$ 1.83	D
Stock Options	⁽¹⁰⁾	04/15/2031	Common Stock	50,000	$ 1.83	D
Stock Options	⁽¹¹⁾	06/30/2031	Common Stock	7,529	$ 1.83	D

Reporting Owners

Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Gryaznov Sergei 444 WEST LAKE STREET, SUITE 1700 CHICAGO, IL 60606			Chief Scientific Officer

Signatures

/s/ Sergei M. Gryaznov		07/27/2022
^**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Mr. Gryaznov beneficially owns 21,511 shares of common stock.
(2)	Represents an option to purchase shares of Common Stock granted pursuant to the 2018 Stock Option Plan. These options fully vested on .December 1, 2019.
(3)	Represents an option to purchase shares of Common Stock granted pursuant to the 2018 Stock Option Plan. These options vested in four equal monthly installments on December 1, 2019.
(4)	Represents an option to purchase shares of Common Stock granted pursuant to the 2018 Stock Option Plan. 6,055 of these options vested on April 30, 2020 and 47,945 of these options vested on January 1, 2021.
(5)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options fully vested on November 3, 2020.
(6)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options vested in 90 equal daily instalments beginning on January 1, 2021.
(7)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options fully vested on May 20, 2021.
(8)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options fully vested on May 20, 2021.
(9)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options vested in 90 equal daily instalments beginning on April 2, 2021.
(10)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options vested in 36 equal monthly instalments beginning on January 1, 2021.
(11)	Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options fully vested on July 1, 2021.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.