Quarterly report pursuant to Section 13 or 15(d)

Commitments And Contingencies - Additional Information (Details)

v3.23.1
Commitments And Contingencies - Additional Information (Details) - USD ($)
 1 Months Ended 3 Months Ended
Feb. 28, 2021
Dec. 31, 2020
Nov. 30, 2018
Mar. 31, 2023
Regeneron        
Loss Contingencies [Line Items]        
Term of agreement 5 years      
THIO | Amended Patent and Technology License Agreement        
Loss Contingencies [Line Items]        
Term of agreement   20 years    
Combined milestone payment maximum   $ 112,000,000    
UTSW | Amended Patent and Technology License Agreement        
Loss Contingencies [Line Items]        
Payments due related to milestones       $ 0
UTSW | Patent and Technology License Agreement        
Loss Contingencies [Line Items]        
Term of agreement   20 years    
Combined milestone payment maximum   $ 112,000,000    
Payments due related to milestones       $ 0
Percentage of royalty description       There are single digit royalty rates for licensed products and licensed services covered by a Valid Claim (as defined in the agreement) and dependent on whether Net Sales are greater than or less than/equal to $1,000,000,000, with Net Sales above that amount commanding a slightly higher percentage. In each case, the royalty percentage is lower before patent issuance in each jurisdiction. In the event that the licensed product or licensed service is not covered by a Valid Claim, the running royalty rates are reduced by fifty percent (50%).
Claim expiration period   10 years    
Minimum | THIO | Amended Patent and Technology License Agreement        
Loss Contingencies [Line Items]        
Milestone payment   $ 1,000,000    
Minimum | THIO | Amended Patent and Technology License Agreement | Net sales up to $1,000,000,000        
Loss Contingencies [Line Items]        
Rate of royalties on net sales     2.00%  
Minimum | THIO | Amended Patent and Technology License Agreement | Net sales above $1,000,000,000        
Loss Contingencies [Line Items]        
Rate of royalties on net sales   2.50%    
Minimum | UTSW | Patent and Technology License Agreement        
Loss Contingencies [Line Items]        
Milestone payment   $ 1,000,000    
Minimum | UTSW | Patent and Technology License Agreement | Net sales up to $1,000,000        
Loss Contingencies [Line Items]        
Rate of royalties on net sales   2.00%    
Minimum | UTSW | Patent and Technology License Agreement | Net sales above $1,000,000,000        
Loss Contingencies [Line Items]        
Rate of royalties on net sales   2.50%    
Maximum | THIO | Amended Patent and Technology License Agreement        
Loss Contingencies [Line Items]        
Milestone payment   $ 50,000,000    
Maximum | THIO | Amended Patent and Technology License Agreement | Net sales up to $1,000,000,000        
Loss Contingencies [Line Items]        
Rate of royalties on net sales     4.00%  
Maximum | THIO | Amended Patent and Technology License Agreement | Net sales above $1,000,000,000        
Loss Contingencies [Line Items]        
Rate of royalties on net sales   5.00%    
Maximum | UTSW | Patent and Technology License Agreement        
Loss Contingencies [Line Items]        
Milestone payment   $ 50,000,000    
Maximum | UTSW | Patent and Technology License Agreement | Net sales up to $1,000,000        
Loss Contingencies [Line Items]        
Rate of royalties on net sales   4.00%    
Maximum | UTSW | Patent and Technology License Agreement | Net sales above $1,000,000,000        
Loss Contingencies [Line Items]        
Rate of royalties on net sales   5.00%